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Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Severina, A. I. | - |
dc.contributor.author | Georgiyants, V. A. | - |
dc.contributor.author | Shtrygol', S. Yu. | - |
dc.contributor.author | Kavraiskyi, D. P. | - |
dc.date.accessioned | 2016-11-24T12:31:56Z | - |
dc.date.available | 2016-11-24T12:31:56Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones as possible anticonvulsant agents / A.I. Severina, V.А. Georgiyants, S.Yu. Shtrygol’, D.P. Kavraiskyi // Der Pharma Chemica. – 2015. – Vol. 7, №11. – P. 43–48. | en_US |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/10817 | - |
dc.description.abstract | The synthesis of 1-(4-bromophenyl)- and 1-(2-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one as possible anticonvulsant agents was planned. It was carried out by the interaction of the corresponding phenylhydrazine hydrochloride with ethyletoxymethylencyanocetate with a further heating of obtained 5-аmino-1- аryl-1H-pyrazole-4-carboxylate in excess of formamide. The direction of reaction of 1-aryl-1,5-dihydro-4Hpyrazolo[ 3,4-d] pyrimidine-4-one with N-arylsubstituted α-chloracetamides, 2-chloro-1-(4-arylpiperazine-1-yl)- ethanone and 2-chloro-N-(4-chlorobenzyl)acetamide in the presence of DMFA-NaHCO3 had been investigated. Using the data of NMR and NOESY spectroscopy it was found out that reaction is selectively performed at 5 position of pyrazolo[3,4-d]pyrimidine system. Due to preliminary prognosis of biological activity pharmacological screening of substances synthesized as possible anticonvulsant agents on the penthyltetrazole seizures was planned | en_US |
dc.language.iso | en | en_US |
dc.publisher | Scholars Research Library | en_US |
dc.subject | synthesis | en_US |
dc.subject | pyrazole | en_US |
dc.subject | alkylation | en_US |
dc.subject | acetamides | en_US |
dc.subject | activity prediction | en_US |
dc.title | Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones as possible anticonvulsant agents | en_US |
dc.type | Article | en_US |
Располагается в коллекциях: | Наукові публікації кафедри фармакологiї та фармакотерапії |
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Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones as possible anticonvulsant agents.pdf | 173,35 kB | Adobe PDF | Просмотреть/Открыть |
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