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Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Severina, A. I. | - |
dc.contributor.author | Georgiyants, V. A. | - |
dc.contributor.author | Shtrygol', S. Yu. | - |
dc.contributor.author | Kavraiskyi, D. P. | - |
dc.date.accessioned | 2016-12-06T12:35:07Z | - |
dc.date.available | 2016-12-06T12:35:07Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Synthesis of N-substituted derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4Н-pyrazolo[3,4-d]pyrimidin-4-one as potential anticonvulsants / A. I. Severina, V. А. Georgiyants, S. Yu. Shtrygol’, D. P. Kavraiskyi // Scripta Scientifica Pharmaceutica. – 2016. – Vol. 3. - №2. – P. 7–11. | en_US |
dc.identifier.issn | 2367-5500 | - |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/10887 | - |
dc.description.abstract | The high psychotropic activity of pyrimidine derivatives attracts attention and leads to the creation of new pyrimidine drugs which affect the central nervous system. As psychotropic agents, special attention deserve azolopyrimidine derivatives, including pyrazolopyrimidines. Thus, among the pyrazolopyrimidine derivatives, compounds with antiepileptic, anticonvulsant, sedative, anxiolytic activity, ligands of benzodiazepine site of GABA receptors have been found. In addition, the ligands of 5HT-6 receptors were identified that are promising for the treatment of central nervous system, muscle relaxants. The purpose of this research was a synthesis of alkylated derivatives of 1-(4-methoxyphenyl)-1,5-dihydro- 4H-pyrazolo[3,4-d]pyrimidine-4-ones | en_US |
dc.language.iso | en | en_US |
dc.publisher | Varna Medical University Press | en_US |
dc.subject | synthesis | en_US |
dc.subject | pyrimidine | en_US |
dc.subject | pyrazole | en_US |
dc.subject | acetamides | en_US |
dc.subject | activity prediction | en_US |
dc.title | Synthesis of n-substituted derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4н- pyrazolo[3,4-d]pyrimidin-4-one as potential anticonvulsants | en_US |
dc.type | Article | en_US |
Располагается в коллекциях: | Наукові публікації кафедри фармакологiї та фармакотерапії |
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Файл | Описание | Размер | Формат | |
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Synthesis of N-substituted derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4Н-pyrazolo[3,4-d]pyrimidin-4-one as potential anticonvulsants.pdf | 296,26 kB | Adobe PDF | Просмотреть/Открыть |
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