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http://dspace.nuph.edu.ua/handle/123456789/11584Полная запись метаданных
| Поле DC | Значение | Язык |
|---|---|---|
| dc.contributor.author | Kulikovska, K.Yu. | - |
| dc.contributor.author | Kovalenko, S. S. | - |
| dc.contributor.author | Drushlyak, O. G. | - |
| dc.contributor.author | Zhuravel, I. O. | - |
| dc.contributor.author | Kovalenko, S. M. | - |
| dc.contributor.author | Куликовська, К. Ю. | - |
| dc.contributor.author | Куликовская, К. Ю. | - |
| dc.contributor.author | Коваленко, С. С. | - |
| dc.contributor.author | Друшляк, А. Г. | - |
| dc.date.accessioned | 2017-03-21T08:31:58Z | - |
| dc.date.available | 2017-03-21T08:31:58Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | Аntimicrobial activity of [1,2,4]triazolo[4,3-а]pyrazin-8(7Н)-one derivatives / K. Yu. Kulikovska, S. S. Kovalenko, O. G. Drushlyak, I. О. Zhuravel, S. M. Kovalenko // Scientific Journal Annals of Mechnikov's Institute (AMI). – 2014. – №4. – Р. 32-38. | en_US |
| dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/11584 | - |
| dc.description | Today the problem of microbial resistance to antibacterial agents becomes the global one. Antimicrobial drugs that are in the parmaceutical market do not satisfy the needs of modern treatment regimens, particularly Hospital- acquired infections. Therefore, the search for new and effective means of this pharmacological group is an important task of medical chemistry. From the literature it is known that derivatives of [1,2,4]triazolo[4,3- a]pyrazine show a wide range of biological actions, including antimicrobial and fungicidal. This makes it relevant microbiological study of primary derivatives of [1,2,4]triazolo[4,3-a]pyrazine for identifying promising compounds of the series and then study it in biological experiment.Using the PASS C&T (Prediction Activity Spectra for Substances: Complex & Training) program and based on published data, we have generated virtual library of derivatives of [1,2,4]triazolo[4,3-a]pyrazine. As a result, we have received 35 new synthetic compounds of 7 series that were not previously described in the literature. | en_US |
| dc.description.abstract | The search for new and effective antimicrobial and antifungal agents is an important task of medical chemistry. In this paper is set out the results of microbiological screening of new derivatives of [1,2,4]triazolo[4,3-a]pyrazine. Investigations have shown that these compounds show moderate antimicrobial activity against standard test systems, and some of them can be used for further modification in order to enhance their influence on the microbial cell. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Annals of Mechnikov Institute | en_US |
| dc.subject | [1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one derivatives | en_US |
| dc.subject | antimicrobial activity | en_US |
| dc.subject | antifungal activity | en_US |
| dc.title | Antimicrobial activity of [1,2,4]triazolo[4,3-А]pyrazin-8(7h)-one derivatives | en_US |
| dc.type | Article | en_US |
| Располагается в коллекциях: | Наукові публікації кафедри загальної хімії | |
Файлы этого ресурса:
| Файл | Описание | Размер | Формат | |
|---|---|---|---|---|
| Куликовська_ami_2014_32-38.pdf | 368 kB | Adobe PDF | Просмотреть/Открыть |
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