Wound healing effect tiotrizoline oinment for action on skin ionizing radiation in rats

Abstract

The wound healing effect "Unguentum Thiotriazolini 2%" (JSC "chemical- pharmaceutical plant" Red Star ", Ukraine)was studied in rats with local radiation skin lesions. The rats were divided into four groups, each comprised of six rats:intact (group 1), radiation injuries of the skin (group 2), radiation injuries of the skin + ointment: methyluracil (group 3) and Thiotriazoline (group 4). Rats of 2, 3 and 4 groups were exposed to X-rays of the hip (80 Gy). In Group 3 and 4 the ointments were applied on the skin 1 hour before exposure and for 10 days after it once a day. On the 35th day of experiment immunomorphological study of focus of exposure (macrophages, cells are producers of interleukins IL-1 and IL-10) was performed.The results showed that the ointment Thiotriazoline (group 4) caused a more pronounced wound healing effect, manifested increased macrophage reaction, restoration of cytokine balance, compared with group 2 and 3.