Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс:
http://dspace.nuph.edu.ua/handle/123456789/13288
Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Suleiman, M. M. | - |
dc.contributor.author | Gritsenko, I. S. | - |
dc.contributor.author | Drugovina, V. V. | - |
dc.contributor.author | Sergienko, E. M. | - |
dc.contributor.author | Сулейман, М. М. | - |
dc.contributor.author | Гриценко, И. С. | - |
dc.contributor.author | Гриценко, І. С. | - |
dc.contributor.author | Друговіна, В. В. | - |
dc.contributor.author | Друговина, В. В. | - |
dc.contributor.author | Сергієнко, О. М. | - |
dc.contributor.author | Сергиенко, Е. М. | - |
dc.date.accessioned | 2017-08-28T10:38:31Z | - |
dc.date.available | 2017-08-28T10:38:31Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Docking studies of the derivatives of 3-oxamoyl(succinoyl)amides of N-phenylanthranilic acids as Inhibitors of enzymes COX-1 and COX-2 / M. M. Suleiman at all. // Der Pharma Chemica. - 2017. - № 9(12). - P. 14-23. | en_US |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/13288 | - |
dc.description.abstract | Conducted docking studies found that pharmacological activity is associated with inhibiting prostaglandin synthesis by new derivatives of N-phenylanthranilic acid by inhibiting enzyme activity by them, involved in different stages of cyclooxygenase pathway of metabolism of arachidonic acid: COX-1, COX-2. The obtained results indicate the possibility of the formation of stable complexes of the molecules of the synthesized substances with COX-1 and COX-2, in which the location of the ligands in the active center of the receptor and the residues of amino acids of side chains, involved in the formation of non-covalent bonds, are analogical to the geometry and types of binding of classical nonsteroidal anti-inflammatory drugs, established basing on crystallographic researches. | en_US |
dc.language.iso | en | en_US |
dc.subject | 3-oxamoyl(succinoyl)amides | en_US |
dc.subject | N-phenylanthranilic acids | en_US |
dc.subject | anti-inflammatory activity | en_US |
dc.subject | analgesic activity | en_US |
dc.subject | docking studies | en_US |
dc.title | Docking studies of the derivatives of 3-oxamoyl(succinoyl)amides of N-phenylanthranilic acids as Inhibitors of enzymes COX-1 and COX-2 | en_US |
dc.type | Article | en_US |
Располагается в коллекциях: | Наукові публікації кафедри медичної хiмiї |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
---|---|---|---|---|
docking-studies-of-the-derivatives-of-3oxamoylsuccinoylamides-of-nphenylanthranilic-acids-as-inhibitors-of-enzymes-cox1-.pdf | 897,86 kB | Adobe PDF | Просмотреть/Открыть |
Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.