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Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Redkin, R. G. | - |
dc.contributor.author | Syumka, E. I. | - |
dc.contributor.author | Shemchuk, L. A. | - |
dc.contributor.author | Chernykh, V. P. | - |
dc.contributor.author | Редькін, Р. Г. | - |
dc.contributor.author | Сюмка, Е. И. | - |
dc.contributor.author | Сюмка, Є. І. | - |
dc.contributor.author | Шемчук, Л. А. | - |
dc.contributor.author | Черних, В. П. | - |
dc.contributor.author | Черных, В. П. | - |
dc.date.accessioned | 2020-01-14T20:16:33Z | - |
dc.date.available | 2020-01-14T20:16:33Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione / / R. G. Redkin, E. I. Syumka, L. A. Shemchuk, V. P. Chernykh // Journal of Applied Pharmaceutical Science. - 2017. - Vol. 7 (06). - Р. 69-78. | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/21045 | - |
dc.description.abstract | The interaction of isatins, α-amino acids and 1,6-bismaleimidohexane has been studied. It was found that for 1'R3-2'-R2-3'-R1-5'-(6-{1'-R3-2'-R2-3'-R1-2,4',6'-trioxo-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'pyrrolo[3,4-c]pyrrole]-5'-yl}hexyl)-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]2,4',6'-triones were formed through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and some α-amino acids with dipolarophile 1,6bismaleimidohexane. This method has the advantages of mild reaction conditions, high atom economy and excellent yields. The most suitable conditions for this reaction are boiling alcohol-water medium. The obtained compounds showed a weak selective antimicrobial activity for the Micrococcaceae family. | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | isatins | uk_UA |
dc.subject | α-amino acids | uk_UA |
dc.subject | 2-oxindoles | uk_UA |
dc.subject | bis-spirocyclic systems | uk_UA |
dc.subject | bis-maleimides | uk_UA |
dc.subject | 1,3-cycloaddition | uk_UA |
dc.subject | antimicrobial activity | uk_UA |
dc.title | Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові публікації В. П. Черних |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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369.pdf | 696,83 kB | Adobe PDF | Просмотреть/Открыть |
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