Experimental study of antimicrobial properties and acute toxicity of the peo-based combined suppositories

Abstract

The metabolite of plant glucosinolates indole-3-carbinol (I3С) is a promising treatment for prostate diseases. The effectiveness of I3С as a component of complex therapy of hormone-dependent diseases of benign prostatic hyperplasia (BPH), prostate carcinoma, uterine fibroids, fibrocystic mastopathy is confirmed. Experimentally demonstrated high antitumor activity of I3С and its metabolite DIM with respect to prostate cancer, the ability to induce cell apoptosis, inhibit the growth of androgen-dependent and androgen-independent cell cultures of this gland. As well as the ability to block the proliferation of signals (in particular, the activation of nuclear transcription factor NF-kB and protein kinase Akt) in prostate cells by inhibiting the expression of androgen receptors, which play an important role in the pathogenesis of BPH. I3С exerts a modulating effect on estrogen receptors (ER) and the number of androgen receptors (AR) Based on its pharmacodynamic characteristics, it can be assumed that I3С may have a complex effect on the mechanisms of BPH and CP.