Structural modification of ciprofloxacin and norfloxacin for searching new antibiotics to combat drug-resistant bacteria

Abstract

The World Health Organization refers to the problem of antibiotic resistance as of one of the huge threats to global health and security. Due to its appearance hospital stays become longer, medical costs and mortali- ty level are increased . All over the world people are influenced by antibiotic resistance as an economic bur- den that decreases the total quality of their lives . Altogether such an extremely negative impact of antibiotic resistance on the health and economic systems definitely needed to be combated. For this purpose now-adays there are at least two global strategies. Firstly, the methods to control the spread of antibiotic resistance towards existing medicines must be created and implied in the health care systems of all countries. Secondly, the scientific community has to intensify the development and implementation of new biologically active molecules that can become novel potent antimicrobials