Research of the toxicological and pharmacological

Abstract

Introduction. A research aim is a toxicological study to the coupage from a digister that is used for making of low-alcoholic drinks. Materials and methods. The drink made the method of natural fermentation contains to the 4,0% alcohol and mixture of extract substances of different plants with high antioxidant ability. Studied subsharp toxicness to the coupage and his influence on the prooxidant-antioxidant state of liver of white mise comparatively with solution of alcohol of 4,0% and beer of 4,0%. Results and discussion. After intragastric introduction to the coupage in a maximal for these animals dose 36,1 g/kg during 14 days of signs of intoxication for animals were not observed. Middle mass of animals (24,33 g) kept indoors outside a physiology norm and did not differ (р > 0,05) from the indexes of middle mass of animals of group of intact control (24,33 g). Mass coefficient of liver (0,1g/10,0g) for the animals of intact control (38,567) and those a coupage (39,467) was entered that, considerably differed from the liver of animals beer (42,867) and solution of ethyl spirit (45,633) was entered that, is beginning of development of scray displays, in particular hypertrophies of organ. A coupage diminishes in general lines toxic influence to the alcohol on the organism of animals that normalizes the coefficient of mass of liver. Biochemical researches of homogenate fabrics are livers of animals a coupage shown that on content in the liver of diene conjugates (3,633 mkmol/g), TBA-reagents (2,500 mkmol/g), renewed glutathione (2,420 mkmol/g) and catalase (0,163 mkmol/min∙g) did not statistically different from the indexes of animals of intact control and been within the limits of physiology norm. In the group of animals beer was entered that, content of renewed glutathione (2,267 mkmol/g) went down and activity of catalase (0,153 mkmol/min∙g) diminished. In the group of animals solution of alcohol was entered that, reliable change (p < 0,05): content of TBA-reagents (3,033 mkmol/g) grew, content of renewed glutathione (2,333 mmol/g) went down and activity of catalase (0,157 mkmol/min∙g) was repressed