http://dspace.nuph.edu.ua/handle/123456789/1147 Mon, 20 Jul 2026 13:07:05 GMT 2026-07-20T13:07:05Z http://dspace.nuph.edu.ua:80/retrieve/bac3068f-9773-4584-91f0-f68d9fd1a07b/loho-kafedry-farmatsevtychnoi-khimii_png.png http://dspace.nuph.edu.ua/handle/123456789/1147 http://dspace.nuph.edu.ua/handle/123456789/37144 Название: Promising biological targets for the design of multitarget neuromodulatory agents Авторы: Bespalenko, D.; Velgan, R.; Severina, H.; Georgiyants, V. Краткий осмотр (реферат): Neuropsychiatric and neurodegenerative disorders, including depression and cognitive impairment, are characterized by complex multifactorial pathophysiology involving dysregulation of multiple neurotransmitter systems, impaired neuroplasticity, and neuroinflammatory processes. Traditional pharmacotherapy targeting a single biological target often demonstrates limited therapeutic efficacy. Therefore, increasing attention has been paid to the concept of multitargetdirected ligands (MTDLs), which involves the design of compounds capable of modulating several key biological targets within the central nervous system simultaneously [1]. Thu, 01 Jan 2026 00:00:00 GMT http://dspace.nuph.edu.ua/handle/123456789/37144 2026-01-01T00:00:00Z http://dspace.nuph.edu.ua/handle/123456789/37143 Название: Non-aqueous DPPH spectrophotometric assay for evaluating lipophilic compounds with tocopherol acetate calibration Авторы: Matus, T.; Ivanauskas, L.; Marksa, M.; Georgiyants, V. Краткий осмотр (реферат): For assessing antioxidant activity of hydrophilic and lipophilic compounds, hydrophilic standards (Trolox, ascorbic acid, gallic acid, rutin, etc.) are most commonly used in spectrophotometric studies. However, for lipophilic substances, it is more appropriate to perform the analysis in non-aqueous conditions and compare their activity with a lipophilic standard. α‑Tocopherol serves as such a standard, demonstrating activity comparable to Trolox (1). Therefore, a DPPH-based method in a non-aqueous medium was developed using α‑tocopherol as a standard and applied to chamomile essential oil Thu, 01 Jan 2026 00:00:00 GMT http://dspace.nuph.edu.ua/handle/123456789/37143 2026-01-01T00:00:00Z http://dspace.nuph.edu.ua/handle/123456789/37142 Название: Prospects for Implementing Continuous Flow Reactors for the Industrial Synthesis of APIs Based on Organometallic Reagents Авторы: Vernydub, M.; Georgiyants, V. Краткий осмотр (реферат): The modern pharmaceutical industry requires the implementation of highly efficient synthesis methods for active pharmaceutical ingredients (APIs) based on "green chemistry" and safety. Using highly reactive organometallic reagents like n-butyllithium in traditional batch processes poses risks of thermal runaway, necessitating extreme cooling (-78 °C) and high energy costs. Continuous flow reactors offer a solution to reduce technological hazards and increase efficiency for such dangerous industrial-scale syntheses Thu, 01 Jan 2026 00:00:00 GMT http://dspace.nuph.edu.ua/handle/123456789/37142 2026-01-01T00:00:00Z http://dspace.nuph.edu.ua/handle/123456789/37141 Название: Selection of conditions for impurities’ determination in combined ibuprofen/caffeine syrup by HPLC Авторы: Surzhikov, I.; Chornyi, V.; Georgiyants, V. Краткий осмотр (реферат): The production of fixed combinations is a modern trend in pharmaceutical manufacturing due to their advantages (1). Recently, a fairly large number of ibuprofen combinations have been present on the pharmaceutical market (2,3). At the same time, such dosage forms may have problems with both the bioavailability of the components and their potential interaction. That is why during the pharmaceutical development of such products it is very important to ensure the absence of any interaction between both the API and the excipients. For this purpose, it is important to have developed methods for the chromatographic separation of the API and impurities in such dosage forms Thu, 01 Jan 2026 00:00:00 GMT http://dspace.nuph.edu.ua/handle/123456789/37141 2026-01-01T00:00:00Z