Синтез, фізико-хімічні та біологічні властивості N-R-амідів 4-гідрокси-2-оксо-1,2-дигідрохінолін-3-карбонових кислот

Abstract

The paper deals with the purposeful search of new biologically active substances in the range of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides and their functional derivatives. The preparatory methods for their obtaining have been offered and the synthesis of the compounds mentioned has been carried out. To confirm the structure of the compounds obtained elemental analysis, spectroscopy NMR 1' and 135, mass spectrometry, $R-spectroscopy, polarimetry and X-ray diffraction analysis have been used. Antituberculosis, diuretic and antithyroid properties of the synthesized substances have been researched. Relationship “structure – biological activity” were found and benzimidazol-2-ylamide of 1-R-4-hydroxy-2-oxo-1,2- dihydroquinoline-3-carboxylic acid as a new perspective non-hormonal antithyroid drug recommend for further research.