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Title: | Docking studies of the derivatives of 3-oxamoyl(succinoyl)amides of N-phenylanthranilic acids as Inhibitors of enzymes COX-1 and COX-2 |
Authors: | Suleiman, M. M. Gritsenko, I. S. Drugovina, V. V. Sergienko, E. M. Сулейман, М. М. Гриценко, И. С. Гриценко, І. С. Друговіна, В. В. Друговина, В. В. Сергієнко, О. М. Сергиенко, Е. М. |
Keywords: | 3-oxamoyl(succinoyl)amides;N-phenylanthranilic acids;anti-inflammatory activity;analgesic activity;docking studies |
Issue Date: | 2017 |
Bibliographic description (Ukraine): | Docking studies of the derivatives of 3-oxamoyl(succinoyl)amides of N-phenylanthranilic acids as Inhibitors of enzymes COX-1 and COX-2 / M. M. Suleiman at all. // Der Pharma Chemica. - 2017. - № 9(12). - P. 14-23. |
Abstract: | Conducted docking studies found that pharmacological activity is associated with inhibiting prostaglandin synthesis by new derivatives of N-phenylanthranilic acid by inhibiting enzyme activity by them, involved in different stages of cyclooxygenase pathway of metabolism of arachidonic acid: COX-1, COX-2. The obtained results indicate the possibility of the formation of stable complexes of the molecules of the synthesized substances with COX-1 and COX-2, in which the location of the ligands in the active center of the receptor and the residues of amino acids of side chains, involved in the formation of non-covalent bonds, are analogical to the geometry and types of binding of classical nonsteroidal anti-inflammatory drugs, established basing on crystallographic researches. |
URI: | http://dspace.nuph.edu.ua/handle/123456789/13288 |
Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
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