The analgesic properties of a promising antidepressant -2-methyl-3-(phenylaminomethyl)-1H-quinolin-4-one

Abstract

The article presents the results of the experimental study of the analgesic properties of a promising antidepressant with the polymodal action on CNS – 2-methyl-3-(phenylaminomethyl)-1H-quinolin-4-one (atristamine). The study was carried out in male mice using the acetic acid-induced writhing test (to evaluate the effect on the visceral type of pain) and the tail immersion test (to estimate the impact on the somatic nociceptive system). Metamizole sodium (500 mg/kg) and imipramine hydrochloride (25 mg/kg) were chosen as reference drugs. The results of the study showed that in the acetic acid-induced writhing test atristamine in the dose of 100 mg/kg had no antinociceptive effect. At the same time, the analgesic activity of this compound in the same dose has been proven in the tail immersion test. It has been shown that atristamine provides antinociception starting not less than in 90 min after introduction and has the optimal effect in the 120-min time point. Certain differences in the analgesic action compared to imipramine have been discussed