Study of improvement of efficiency of drug substance liposomal delivery systems, as well as of delivery systems by means of carbon nanotubes

Abstract

Abstract: In order to increase the efficiency of liposomal delivery systems (LDS) for drug substance (DS) delivery to target cells the concept of creation of LDS with two or three active DS (“self-organizing LDS”) is proposed and in a number of cases experimentally confirmed, where some DS beside pharmacological activity are capable to provide structuring function - change liposome membrane charge and respectively change the affinity to liposome membranes of other oppositely charged pharmacologically active DS in liposomes; reduce membrane fluidity and respectively reduce DS efflux from liposomes; capable to charge at the final stage at fusion with target cells the membranes of these cells and facilitate oppositely charged active DS more effective penetration into target cells. New experimental data on the fact that change of target cell membrane charge by means of introduction of iono genic surfactants substantially increases the affinity of carbon nanotubes (CNT) with opposite charge are obtained. In these cases ion-ion interactions of CNTs with oppositely charged membranes of target cells can act as the main motive force of DS delivery vector and improve efficiency of delivery systems by means of nanotubes. It is also possible to use charged CNTs carrying DS with charge opposite to target cell membrane charge.