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http://dspace.nuph.edu.ua/handle/123456789/15269
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Shovkova, O. V. | - |
dc.contributor.author | Klimenko, L. Yu. | - |
dc.contributor.author | Kovalenko, Sv. M. | - |
dc.contributor.author | Zhukova, T. V. | - |
dc.contributor.author | Шовкова, О. В. | - |
dc.contributor.author | Клименко, Л. Ю. | - |
dc.contributor.author | Коваленко, Св. Н. | - |
dc.contributor.author | Жукова, Т. В. | - |
dc.contributor.author | Шовковая, О. В. | - |
dc.contributor.author | Клименко, Л. Ю. | - |
dc.contributor.author | Коваленко, Св. Н. | - |
dc.contributor.author | Жукова, Т. В. | - |
dc.date.accessioned | 2018-05-03T07:17:57Z | - |
dc.date.available | 2018-05-03T07:17:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Development and validation of UV-spectrophotometric procedures for secnidazole quantitative determination / O. V. Shovkova, L. Yu. Klimenko, Sv. M. Kovalenko, T. V. Zhukova // J. Pharm. Sci. & Res. – 2017.– № 9 (4). – Р. 338-348. | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/15269 | - |
dc.description.abstract | Secnidazole is one of the antiprotozoal medicines from the group of 5-nitroimidazoles, which is characterized by a prolonged serum half-life. For secnidazole determination the method of HPLC is widely used, but secnidazole is applied in high concen-tration and less sensitive methods of analysis such as spectrophotometry may be useful for its quantification. The aim is to de-velop a number of UV-spectrophotometric procedures of secnidazole quantification and carry out step-by-step validation of the developed procedures. UV-spectra of secnidazole in 0.1 M hydrochloric acid solution (A), 96% ethanol (B), 0.1 M potassium hydroxide solution in methanol (C), 0.1 M sodium hydroxide solution (D) have been investigated and it has been set that when in-creasing the рНvalue step-by-step shift of substance maximum absorption to the right is observed (277 nm →310 nm →314 nm →319 nm). The procedures of secnidazole quantitative determination by the method of UV-spectrophotometry have been devel-oped using the mentioned solvents and wavelengths respectively. Their validation by such parameters as stability, linearity, accu-racy and precision in the variants of the method of calibration curve and method of standard has been carried out. The proce-dures A, B and D of secnidazole quantitative determination are acceptable for application. The best linearity, accuracy and re-peatability have been fixed for the procedure D in the variant of the method of calibration curve. | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | secnidazole | uk_UA |
dc.subject | UV-spectrophotometry | uk_UA |
dc.subject | validation | uk_UA |
dc.subject | method of calibration curve | uk_UA |
dc.subject | method of standard | uk_UA |
dc.subject | сенідазол | uk_UA |
dc.subject | УФ-спектрофотометрія | uk_UA |
dc.subject | перевірка | uk_UA |
dc.subject | метод калібрування кривої | uk_UA |
dc.subject | метод стандарту | uk_UA |
dc.subject | секнидазол | uk_UA |
dc.subject | УФ-спектрофотометрии | uk_UA |
dc.subject | проверка | uk_UA |
dc.subject | метод калибровочной кривой | uk_UA |
dc.subject | метод стандартного | uk_UA |
dc.title | Development and validation of UV-spectrophotometric procedures for secnidazole quantitative determination | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові публікації кафедри організації та економіки фармації |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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3_J. Pharm. Sci. & Res. Vol. 9(4), 2017,.pdf | 1,11 MB | Adobe PDF | Просмотреть/Открыть |
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