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http://dspace.nuph.edu.ua/handle/123456789/19954Полная запись метаданных
| Поле DC | Значение | Язык |
|---|---|---|
| dc.contributor.author | Drapak, I. V. | - |
| dc.contributor.author | Zimenkovsky, B. S. | - |
| dc.contributor.author | Perekhoda, L. O. | - |
| dc.contributor.author | Kovalenko, S. M. | - |
| dc.contributor.author | Logoyda, L. | - |
| dc.contributor.author | Драпак, І. В. | - |
| dc.contributor.author | Зіменковський, Б. С. | - |
| dc.contributor.author | Перехода, Л. О. | - |
| dc.contributor.author | Коваленко, С. М. | - |
| dc.contributor.author | Логойда, Л. | - |
| dc.date.accessioned | 2019-10-11T07:35:01Z | - |
| dc.date.available | 2019-10-11T07:35:01Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | LC-MS/MS method development and validation for the determination of cardiazol in human plasma / I. V. Drapak, B. S. Zimenkovsky, L. O. Perekhoda, S. M. Kovalenko, L. Logoyda // Int. J. App. Pharm. – 2019. – Vol. 11. – Р. 380-385. | uk_UA |
| dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/19954 | - |
| dc.description | The total chromatographic run time was 2.5 min and the elution of cardiazol and IS (difenoconazole) occurred at ~2.15 and 1.98 min, respectively. A linear response function was established at 1-100 ng/ml for cardiazol and difenoconazole in human plasma. The % mean recovery for cardiazol in LQC, MQC and HQC was 102.8 %, 100.3 % and 95.9 %. The lowest concentration with the RSD<20% was taken as LLOQ and was found to be 1.10 ng/ml for cardiazol. The % accuracy of LLOQ samples prepared with the different biological matrix lots was found 109.7 %, which were found within the range of 80.00-120.00 % for the seven different plasma lots. % CV for LLOQ samples was observed as 11.9 %, which are within 20.00% of the acceptance criteria. The within-run coefficients of variation ranged between 0.311 % and 0.601 % for cardiazol. The within-run percentages of nominal concentrations ranged between 99.80 % and 100.41 % for cardiazol. The between-run coefficients of variation ranged between 0.332 % and 0.615 % for cardiazol. The between-run percentages of nominal concentrations ranged between 98.18 % and 101.21 % for cardiazol. | uk_UA |
| dc.description.abstract | The main purpose of this study was to develop a simple, precise, rapid and accurate method for the quantification of cardiazol in human plasma. | uk_UA |
| dc.language.iso | en | uk_UA |
| dc.publisher | International Journal of Applied Pharmaceutics | uk_UA |
| dc.subject | LC-MS/MS | uk_UA |
| dc.subject | Cardiazol | uk_UA |
| dc.subject | Human plasma | uk_UA |
| dc.subject | Validation | uk_UA |
| dc.subject | Pharmacokinetic studies | uk_UA |
| dc.title | LC-MS/MS method development and validation for the determination of cardiazol in human plasma | uk_UA |
| dc.type | Article | uk_UA |
| Располагается в коллекциях: | Наукові публікації кафедри фармацевтичної хімії | |
Файлы этого ресурса:
| Файл | Описание | Размер | Формат | |
|---|---|---|---|---|
| 33482-Article Text-161101-1-10-20190708.pdf | 300,35 kB | Adobe PDF | Просмотреть/Открыть |
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