Synthesis of biologically active substances in the range of 4,5-disubstituted 1,3-thiazoline derivatives

Abstract

Oxidative stress is defined as a disturbance in the equilibrium between free radicals (FR), reactive oxygen species (ROS) and the endogenous defense mechanisms. It is the disturbance in the balance between oxidant-antioxidant states which favours the production of oxidant species. Human body requires both oxidant and antioxidant species for normal metabolism, signal transduction and regulation of cellular functions. Therefore, each cell maintains a condition of homeostasis between the oxidant and antioxidant species. Oxidative stress may lead to injury to all the important cellular components like proteins, DNA and membrane lipids, which can cause cell death. Oxidative stress has also implicated in various physiological and pathological processes, including DNA damage, proliferation, cell adhesion, and survival which has been validated by several experimental and clinical data in large number of pathological states as well as aging.