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http://dspace.nuph.edu.ua/handle/123456789/20954
Title: | Search for biologically active substances among new derivatives of 1,3-thiazole |
Authors: | Maururi, I. Murodov, Sh. Drapak, I. V. Yaremenko, V. D. Suleiman, M. M. Perekhoda, L. O. Драпак, І. В. Драпак, И. В. Яременко, В. Д. Сулейман, М. М. Перехода, Л. О. Перехода, Л. А. |
Keywords: | biologically active substances;derivatives of 1,3-thiazole |
Issue Date: | 2019 |
Bibliographic description (Ukraine): | Search for biologically active substances among new derivatives of 1,3-thiazole / I. Maururi, Sh. Murodov, I. V. Drapak, V. D. Yaremenko, M. M. Suleiman, L. O. Perekhoda // Perspectives of science and education : 8th International youth conference, New York, March 29th, 2019. - New York, 2019. – P. 162-165. |
Abstract: | Analysis of the scientific literature indicates that the derivatives of thiazole have a sufficiently wide spectrum of pharmacological activity and a large number of drugs is created on their basis. But despite a large number of publications, there is practically no information in the literature on the physical, chemical and biological properties of compounds that have piperazine, 1,3-thiazole cycles and phenyl fragments together in their structure. As initial substances to synthesize new derivatives of N1-(4-(4-R- phenyl)-1,3thiazolyl-2)-N1-(4'-R'-phenyl)acetamide and ethyl-[2-[R-imin]-4-methyl-3-R1-2,3dihydro-1,3-thiazole-5-carboxylate the asymmetrical thioureas. Prediction of pharmacological activity for new derivatives of N1-(4-(4-Rphenyl)-1,3-thiazolyl-2)-N1-(4'-R'-phenyl)acetamide is made using the PASS program. According to the results obtained, the synthesized compounds have a wide range of pharmacological activity and act as inhibitor ACE, calcium channel N-type blocker, mucomembranous protector, insulin promoter, ubiquinol-cytochrome-c reductase inhibitor, transcription factor STAT3 inhibitor etc. Pharmacological screening for ethyl-[2-[R-imin]-4-methyl-3-R1-2,3-dihydro1,3-thiazole-5-carboxylate hydrochlorides has shown that the obtained substances possess cardiotropic activity. |
URI: | http://dspace.nuph.edu.ua/handle/123456789/20954 |
Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
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File | Description | Size | Format | |
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NEW_YORK_29032019 (2).pdf | 250,71 kB | Adobe PDF | View/Open |
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