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dc.contributor.authorVlasov, S. V.-
dc.contributor.authorKovalenko, S. M.-
dc.contributor.authorChernykh, V. P.-
dc.contributor.authorВласов, С. В.-
dc.contributor.authorКоваленко, С. М.-
dc.contributor.authorЧерних, В. П.-
dc.contributor.authorВласов, С. В.-
dc.contributor.authorКоваленко, С. Н.-
dc.contributor.authorЧерных, В. П.-
dc.date.accessioned2020-01-14T20:13:46Z-
dc.date.available2020-01-14T20:13:46Z-
dc.date.issued2015-
dc.identifier.citationVlasov, S. V. Synthesis and the antimicrobial activity study of the novel derivatives of 4-oxo- and 4-thio-5-methyl-6-(1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidines / S. V. Vlasov, S. M. Kovalenko, V. P. Chernykh // Journal of Chemical and Pharmaceutical Research. - 2015. - № 7 (4). - P. 1043-1048.uk_UA
dc.identifier.urihttp://dspace.nuph.edu.ua/handle/123456789/21043-
dc.description.abstractThe methods for preparation of novel derivatives of ethyl 5-(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6yl)-1,2,4-oxadiazole-3-carboxylate, 3-substituted 5-methyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidin4(3H)-ones and 4-(alkylthio)-5-methyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidines starting from 5methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid have been developed. The results of the antimicrobial activity screening, performed by agar well diffusion method, for the compounds synthesized showed that ethyl 5-(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)-1,2,4-oxadiazole-3-carboxylate and its 3 pmethylbenzyl derivative together with 5-methyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidine-4(3H)thione and its 4-S-alkyl derivatives are active against the Candida albicans fungi, while 2-[5-methyl-4-oxo-6-(3phenyl-1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidin-3(4H)-yl]-N-phenylacetamide significantly inhibited the growth of Staphylococcus aureus and Bacillus subtilis bacterial strainsuk_UA
dc.language.isoenuk_UA
dc.subjectthiopheneuk_UA
dc.subjectpyrimidineuk_UA
dc.subject1,2,4-oxadiazoleuk_UA
dc.subjectthioneuk_UA
dc.subjectalkylationuk_UA
dc.titleSynthesis and the antimicrobial activity study of the novel derivatives of 4-oxo- and 4-thio-5-methyl-6-(1,2,4-oxadiazol-5-yl)thieno[2,3-d]pyrimidinesuk_UA
dc.typeArticleuk_UA
Располагается в коллекциях:Наукові публікації В. П. Черних

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