Research Of Rheological Properties Of Ointment With WaterSoluble Protein-Polysaccharide Complex Of Oyster Mushroom

Abstract

The problem of the treatment of scar tissue of the skin is quite relevant. This is due to a large number of patients with this pathology, frequency and unpredictable manifestation of scarring, which greatly affects the quality of human life and causes a lot of inconveniences. Today, there are many methods and tools for treating and preventing scar tissue, but the most common use is the use of soft dosage forms. Goal. A goal is an investigation of the structural and mechanical properties of emulsion ointment compositions with a watersoluble protein-polysaccharide complex (WSPPC) of Oyster mushroom and the establishment of an optimal concentration of emulsifier in their composition. Methods. In the process of producing and storing soft dosage forms objective control of quality can be used for study their rheological performance. The objects of the study were ointment compositions on emulsion bases, the active substance of which was a water-soluble protein-polysaccharide complex of Oyster mushroom. The study of the structural and mechanical properties was carried out using a rotary viscometer «Rheolab QC» (Anton Paar, Austria). Research results. Rheological properties characterize the consistency of soft dosage forms which affect the basic technological and consumer characteristics of the dosage form. Thus most ointments under the action of mechanical forces behave as elastic bodies characterized by reversible deformation. Conclusions. The structural and mechanical properties of soft dosage forms depend on the concentration and nature of the emulsifier. During the study it was found that all ointment compositions are structured systems as well as the most optimal composition of the ointment, which provides the necessary thixotropic properties.