The influence of immune activity compounds to the blood serum Cytotoxicity and the leptin level in the conditions of Hypoestrogenia

Abstract

The estrogen activity decrease during the menopause causes changes in metabolic processes and is the principal pathogen factor of post-menopause metabolic syndrome (MS) development. In turn, MS is the risk factor of diabetes mellitus, cardiovascular, autoimmune and other chronic diseases with women at menopause [1]. The level of adipose tissue hormones, in particular, of leptin, correlates with the main components of MS, including obesity, insulin resistance, low intensity inflammation, enhancement of atherogenesis processes [2]. We showed the positive impact of immunotropic pharmacological compounds to the metabolic status with overiaectomized (OVE) rats with MS on the model of estrogen deficiency. The purpose of the work was to study the changes of blood serum cytotoxicity and leptin concentration with the ovariaectomized rats with MS and in the conditions of levamisole immune activity compounds application and its derivate PL-308.