Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс:
http://dspace.nuph.edu.ua/handle/123456789/22447
Название: | Comparative study of the original technology of micronization of the purified flavonoid fraction of “Detralex®” and the technology of micronization of drugs D and N of the Ukrainian manufacturers |
Авторы: | Zupanets, I. A. Shebeko, S. K. Zimin, S. M. Зупанець, І. А. Зупанец, И. А. Шебеко, С. К. Зімін, С. М. Зимин, С. М. |
Ключевые слова: | chronic venous insufficiency;diosmin;granules;hesperidin;tablets matrix |
Дата публикации: | 2018 |
Библиографическое описание: | Zupanets, I. A. Comparative study of the original technology of micronization of the purified flavonoid fraction of “Detralex®” and the technology of micronization of drugs D and N of the Ukrainian manufacturers / I. A. Zupanets, S. K. Shebeko, S. M. Zimin // Asian Journal of Pharmaceutical and Clinical Research. - 2018. - Vol 11, Iss.10. - P. 504-508. |
Краткий осмотр (реферат): | Objective: The objective of the study was to compare the degree of micronization of the bioflavonoid fraction (90% diosmin and 10% hesperidin) of different manufacturers which used for the treatment of the chronic venous insufficiency. Methods: “Detralex®,” medicines N and D, 500 mg coated tablets each were used as studied objects. Microscopy of the tablets matrix of the investigational drugs was performed after spontaneous decomposition in a water solution at pH=6.8, using a modular light field microscope of the research class B-1000BF (Optika, Italy) with a digital camera Optikam HDMI Pro (Optika, Italy) with measuring of the size of the flavonoid fraction granules. Results : About 92.8% of the granules of the “Detralex®” tablets matrix were presented by the smallest size of the granules (1–5 μ), unlike D and N, in which 12.9% and 10% of the same size granules were observed. Giant granule size (up to 50 μm) was discovered in D and N tablets matrix and no such granules size were found in the “Detralex®” tablets matrix. Conclusion: Different degrees of micronization of the purified flavonoid fraction in the studied test samples indicate that the drugs D and N are not pharmaceutically equivalent to the original “Detralex®” drug and cannot be considered as copies without further research. |
URI (Унифицированный идентификатор ресурса): | http://dspace.nuph.edu.ua/handle/123456789/22447 |
ISSN: | 2455-3891 |
Располагается в коллекциях: | Наукові публікації кафедри клінічної фармакології та клінічної фармації |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
---|---|---|---|---|
28140-140187-1-PB.pdf | 6,41 MB | Adobe PDF | Просмотреть/Открыть |
Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.