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http://dspace.nuph.edu.ua/handle/123456789/22587
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Mishchenko, M. V. | - |
dc.contributor.author | Shtrygol', S. Yu. | - |
dc.contributor.author | Kaminskyy, D. | - |
dc.contributor.author | Lesyk, R. | - |
dc.contributor.author | Мищенко, М. В. | - |
dc.contributor.author | Міщенко, М. В. | - |
dc.contributor.author | Штрыголь, С. Ю. | - |
dc.contributor.author | Штриголь, С. Ю. | - |
dc.contributor.author | Камінський, Д. | - |
dc.contributor.author | Лесик, Р. | - |
dc.date.accessioned | 2020-05-11T20:35:36Z | - |
dc.date.available | 2020-05-11T20:35:36Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Thiazole-bearing 4-thiazolidinones as new anticonvulsant agents / M. Mishchenko, S. Shtrygol’, D. Kaminskyy, R. Lesyk // Sci. Pharm. – 2020. – Vol. 88, № 16. doi:10.3390/scipharm88010016 | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/22587 | - |
dc.description.abstract | Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores. The structure of target compounds was based on the following: (i) A combination of two thiazole cores; (ii) similarity to ralitolin’s structure; (iii) the compliance with structural requirements for the new anticonvulsants. Target compounds were synthesized via known approaches based on Knoenavegel reaction, alkylation reaction, and one-pot three-component reaction. Anticonvulsant properties of compounds were evaluated in two different models—pentylenetetrazole-induced seizures and maximal electroshock seizure tests. Among the tested compounds 5Z-(3-nitrobenzylidene)-2-(thiazol-2-ylimino)-thiazolidin-4-one Ib, 2-[2,4-dioxo-5-(thiazol-2- ylcarbamoylmethyl)-thiazolidin-3-yl]-N-(2-trifluoromethylphenyl)acetamide IId and (2,4-dioxo-5- (thiazol-2-ylcarbamoylmethylene)-thiazolidin-3-yl)acetic acid ethyl ester IIj showed excellent anticonvulsant activity in both models. The directions of compounds modification based on SAR aspects were discussed. The results of the study provide a basis for further study of the anticonvulsant properties of selected thiazole-thiazolidinones. | uk_UA |
dc.description.sponsorship | none | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | 4-thiazolidinones | uk_UA |
dc.subject | thiazoles | uk_UA |
dc.subject | synthesis | uk_UA |
dc.subject | anticonvulsant activity | uk_UA |
dc.title | Thiazole-bearing 4-thiazolidinones as new anticonvulsant agents | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові видання кафедри фармакології та фармакотерапії |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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Thiazole-Bearing 4-Thiazolidinones as New anticonvulsant agents.pdf | 987,81 kB | Adobe PDF | Просмотреть/Открыть |
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