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Title: Choice of mucosal adhesive in the composition of a new dental gel
Authors: Maslii, Yu. S.
Рубан, О. А.
Левачкова, Ю. В.
Колісник, Т. Є.
Гуреєва, С. М.
Маслий, Ю. С.
Маслій, Ю. С.
Рубан, Е. А.
Ruban, O. A.
Levachkova, Yu. V.
Kolisnyk, T. Ye.
Колесник, Т. Е.
Keywords: mucosal adhesive;dental gel
Issue Date: 2020
Bibliographic description (Ukraine): Choice of mucosal adhesive in the composition of a new dental gel / Yu. S. Maslii, O. A. Ruban, Yu. V. Levachkova, Svitlana Gureyeva, T. Ye. Kolisnyk // Pharmakeftiki. – 2020. – Vol. 32, Issue 1. – P. 40-49.
Abstract: One of the common disadvantages of dental dosage forms is the short-term therapeutic action due to the contact with saliva that dilutes medications, reducing the time of drug exposure on the mucous membranes. To overcome this point, the mucosal adhesives may be added in dental formulations. Therefore, the aim of this work was to study the effect of different adhesive polymers on properties of the dental gel prepared from Carbomer Polacril® 40Pbasis containing as APIs a combination of tincture «Phytodent», choline salicylate 80 % and lidocaine hydrochloride. The mucosal adhesives used in this study were polyvinylpyrrolidone PVP K90, hydroxypropyl methylcellulose HPMC 2208 90SH-100000 and OraRez®W-100L16. In order to choose a mucoadhesive polymer in dental gel formulation the microbiological, rheological, adhesion and osmotic characteristics have been investigated. Compared with the Carbomer Polacril® 40P gel the addition of mucosal adhesives has slightly improved the release of APIs from the gel base, however there are no statistically significant differences in the antimicrobial activity of the test samples. All the samples are non-Newtonian thixotropic systems and the gel with OraRez® W-100L16 has the closest rheological behavior to the reference drug – currently marketed dental gel. The rising of OraRez® W-100L16 concentration from 1.0 % to 1.5% and 2.0 % leads to the increase of gel viscosity and improving the structural-mechanical properties of semisolid dosage form. Adhesion capacity is also improved by the addition of 1.5 % of mucoadhesive polymer, but further increase up to 2.0 % has no positive effect. The osmotic activity of dental gel samples is not observed to be affected by the change of OraRez® W-100L16 concentration.
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