Conducting postcompressional tests to evaluate the quality of compressed medicated chewing gum for dental use

Abstract

Medicated chewing gum (MCG) is one of the most promising drug delivery system for the treatment of various dental diseases, which provides high therapeutic level of the active substance in the saliva. One of the way to obtain MCG is a compression method, which facilitates and expands the possibilities of manufacturing this dosage form at pharmaceutical enterprises using ordinary tablet machines. The aim of this study was to evaluate the effect of compression force applied during production of MCG with lysozyme hydrochloride and ascorbic acid based on the chewing composition HiG PWD 01 on technological, textural and biopharmaceutical parameters.