Pre-clinical study of the effect of oligopeptides-homologues of the ACTH15-18 fragment on the adrenal glands histostructure in rats on the model of acute hypothermia

Abstract

Disturbances in the peptidergic system functioning under the influence of stress factors is aiming to find substances that can eliminate disintegration in this component of pathogenesis. The study of oligopeptides-homologues of the ACTH15-18 fragment is a promising direction. Our previous studies established their effect on behavioral responses, anxiety, exercise tolerance and carbohydrate metabolism in rats under acute hypothermia. The aim of the current study is to evaluate the oligopeptides influence on the adrenal glands histostructure in rats on the model of acute hypothermia. It has been shown that keeping reserve capabilities, oligopeptides KK-1 and KK-5 increase the resistance of the adrenal cortex to acute cold stress