Study of the stress-protective effect of the combination of glycine with magnesium citrate

Abstract

Stress is one of the most common diseases, which results in a number of comorbidities - coronary heart disease, intestinal disease and others. Therefore, it is important to develop new drugs that would be effective and safe for the treatment and prevention of stress. Since it is important to determine the amount of API to determine the optimal composition and technology of drug production, the aim of the research was to study the effect of glycine, different doses of magnesium citrate and the combination of glycine with magnesium citrate on the functional state of the central nervous system. The most pronounce inhibitory effect on the locomotor activity of animals, indicative research activity and emotional reactions were observed when using a combination of glycine: magnesium citrate at a dose of 100: 350 mg, respectively.