Experimental substantiation of the composition of orally disintegrating tablets

Abstract

Orally Disintegrating Tablets (ODT) represent a modern trend in solid dosage form development. Significant advantages of ODT, in comparison with traditional tablets, include the convenience of administration (due to no need to drink water) and the rapid onset of a therapeutic effect. The main tasks to be solved in the development of ODT are the fast disintegration and providing the required mechanical strength in accordance with pharmacopoeial requirements. The solution is to use appropriate binders, disintegrants and optimal pressing pressure.