Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс:
http://dspace.nuph.edu.ua/handle/123456789/25772
Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Mishchenko, M. | - |
dc.contributor.author | Shtrygol’, S. | - |
dc.contributor.author | Lozynskyi, A. | - |
dc.contributor.author | Khomyak, S. | - |
dc.contributor.author | Novikov, V. | - |
dc.contributor.author | Karpenko, O. | - |
dc.contributor.author | Holota, S. | - |
dc.contributor.author | Lesyk, R. | - |
dc.date.accessioned | 2021-09-16T11:03:52Z | - |
dc.date.available | 2021-09-16T11:03:52Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Evaluation of anticonvulsant activity of dual COX-2/5-LOX inhibitor darbufelon and its novel analogues / Mariia Mishchenko [et al.] // Sci. Pharm. - 2021. - 89 (2). | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/25772 | - |
dc.description.abstract | Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present paper, evaluation of the anticonvulsant activity of the potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using an scPTZ model in mice in dose 100 mg/kg is reported. Darbufelone possesses anticonvulsant properties in the scPTZ model and presents interest for in-depth studies as a possible anticonvulsant multi-target agent with anti-inflammatory activity. The series of 4-thiazolidinone derivatives have been synthesized following the analogue-based drug design and hybrid-pharmacophore approach using a darbufelone matrix. The synthesized derivatives showed a significant protection level for animals in the scPTZ model and are promising compounds for the design of potential anticonvulsants with satisfactory drug-like parameters. | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | 4-thiazolidinones | uk_UA |
dc.subject | darbufelone | uk_UA |
dc.subject | dual COX-2/5-LOX inhibitor | uk_UA |
dc.subject | pentylenetetrazole seizure | uk_UA |
dc.subject | anticonvulsant activity | uk_UA |
dc.title | Evaluation of anticonvulsant activity of dual COX-2/5-LOX inhibitor darbufelon and its novel analogues | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові публікації кафедри фармакологiї та фармакотерапії |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
---|---|---|---|---|
Evaluation of Anticonvulsant Activity of Dual COX-2-5-LOXInhibitor Darbufelon and Its Novel Analogues.pdf | 1,8 MB | Adobe PDF | Просмотреть/Открыть |
Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.
Инструменты администратора