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http://dspace.nuph.edu.ua/handle/123456789/28695
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Sych, Igor | - |
dc.contributor.author | Drapak, Iryna | - |
dc.contributor.author | Suleiman, Marharyta | - |
dc.contributor.author | Rakhimova, Maryna | - |
dc.contributor.author | Kobzar, Natalya | - |
dc.contributor.author | Sych, Irina | - |
dc.contributor.author | Perekhoda, Lina | - |
dc.contributor.author | Сич, І. В. | - |
dc.contributor.author | Драрак, І. В. | - |
dc.contributor.author | Сулейман, М. М. | - |
dc.contributor.author | Рахімова, М. В. | - |
dc.contributor.author | Кобзар, Н. П. | - |
dc.contributor.author | Сич, І. А. | - |
dc.contributor.author | Перехода, Л. О. | - |
dc.date.accessioned | 2022-12-03T19:40:29Z | - |
dc.date.available | 2022-12-03T19:40:29Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Search for biologically active substances with antimicrobial and antifungal action in the series of 2.5-disubstituted 1,3,4-tiadiazoles / I. V. Sych // Research J. Pharm. and Tech. - 2019. - № 12 (5). - P. 1-6. | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/28695 | - |
dc.description.abstract | A range of derivatives of sulfonyl-substituted nitrogen-containing heterocyclic systems has been extended by synthesis of 2N (R)-5R1-1,3,4-thiadiazol-2-yl-arylsulfonamides and N-(diethylsulfamoyl)-N-(5-ethyl-1,3,4- thiadiazol-2-yl)benzamides. It was established that acylation of 5-ethylsulfanyl-1,3,4-thiadiazole-2-amine by heteryl-substituted acid chlorides allowed for obtaining not reported in the literature heterocyclic compounds, which structure contained two cycles of 1,3,4-thiadiazole. The structure and purity of the obtained compounds was confirmed by 1Н NMR-spectroscopy, elemental analysis, and thin-layer chromatography. Pharmacological studies on antimicrobial and antifungal activity have shown that all the compounds tested have sensitivity to both Gram-positive, and Gram-negative bacteria. In addition, the obtained substances have exhibited antifungal activity against Candida albicans. The studies have identified compound 4-butoxy-N-{5-[({[5- (ethylsulfanyl)-1,3,4-thiadiazol-2-yl] carbomoyl} methyl) sulfanyl] -1,3,4-thiadiazol-2-yl} benzamide with high antimicrobialactivity further studies of which are promising. | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | synthesis | uk_UA |
dc.subject | 2.5-disubstituted 1, 3, 4-tiadiazoles | uk_UA |
dc.subject | antibacterial and antifungal activity | uk_UA |
dc.title | Search for biologically active substances with antimicrobial and antifungal action in the series of 2.5-disubstituted 1,3,4-tiadiazole | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові публікації кафедри медичної хiмiї |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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RJPT.pdf | 391,65 kB | Adobe PDF | Просмотреть/Открыть |
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