Study of the degradation behavior of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate in the soil by the GC-Fid method

Abstract

The aim. To study the behaviour of enisamium iodide, thiloron dihydrochloride, morpholinium thiazotate, and the suitability of the previously developed GC-FID methodology in soil. Materials and methods. The determination of the Enisamium iodide, Tilorone dihydrochloride, and Morpholinium thiazotate in soil gas chromatography with a flame ionization detector using the Rxi-5 ms (30 m long, 0.25 mm outer diameter and 0.25 μm liquid stationary phase thickness). Results. A study was conducted on the behaviour of enisamium iodide, thiloron dihydrochloride, and morpholinium thiazotate in soil, along with the assessment of the suitability of the developed GC-FID methodology for determination in soil. The half-life in soil was investigated, which amounted to 45 days for enisamium iodide, 30 days for thilorone dihydrochloride, and 7 days for morpholinium thiazotate, with corresponding decay rate constants of 0.001 mg/mL, 0.001 mg/mL, and 0.0005 mg/mL, respectively. Conclusions. The previously developed GC-FID methodology is suitable for the determination of enisamium iodide, thilorone dihydrochloride, and morpholinium thiazotate in soil, with necessary analysis conditions established. Under aerobic conditions, the selected pharmaceutical preparations’ dispersion rate followed the following decreasing order: enisamium iodide>thilorone dihydrochloride>morpholinium thiazotate in soil.