Microbiome and natural remedies in treatment of dermatological diseases

Abstract

Acne vulgaris, a chronic inflammatory skin condition, remains one of the most prevalent skin disorders globally, affecting millions, particularly during adolescence. While traditionally associated with hormonal fluctuations, excess oil production, and blocked pores, many research also highlights the significant role of the gut and skin microbiome and probiotics in the pathogenesis and management of acne. The pathogenesis of acne occurring by dysbiosis, and it's refers to an imbalance of microbial species and reduction of microbial diversity within certain bodily micro- biomes i.e., the accumulation of microorganisms existing in a specific part of the human body. The human gut microbiota plays a significant role in maintaining gut- skin homeostasis, and whole body. Disruption of this equilibrium is characterized by the overgrowth of some bacterial species, pathogens, fungal and an overall loss of community diversity. The dysbiosis can lead to chronic diseases impaired wound healing, increased inflammation, and greater risk for diverse infection in the body and on the skin. Dysbiosis take to metabolic deregulation that affect immunologically the skin barrier. This article delves into the intricate relationship between the microbiome, probiotics, natural components and acne, exploring how manipulating these factors may lead to effective therapeutic strategies.