Theoretical studies on the anti-inflammatory activity of hyperoside with the phospholipase A2 enzyme

Abstract

Phospholipase A2 catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid, a precursor of eicosanoids including prostaglandins and leukotrienes. These products are precursors of bioactive eicosanoids and platelet-activating factor which have been implicated in pathological states of numerous acute and chronic disorders. So, the aim of our study was to perform molecular docking of hyperoside with the phospholipase A2 enzyme