Theoretical studies on the anti-inflammatory activity of hyperoside with the nuclear factor - KB enzyme

Abstract

The NF-κB pathway is widely recognized as a key proinflammatory signaling mechanism due to its role in regulating the expression of proinflammatory genes, including cytokines, chemokines, and adhesion molecules. Its activation is triggered by proinflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). NF-κB plays a crucial role in the development of chronic inflammatory diseases, including rheumatoid arthritis.