Theoretical studies on the antioxidant activity of hyperoside with the NADPH oxidase enzyme

Abstract

NADPH oxidase is an enzyme responsible for the intentional generation of reactive oxygen species (ROS) and plays a key role in regulating redox-dependent processes in various biological systems. It is found both in phagocytic and nonphagocytic cells. This enzyme facilitates the transfer of electrons from intracellular NADPH across the membrane, combining them with molecular oxygen to form superoxide anion, a highly reactive free radical. As a result, NADPH oxidase is a critical contributor to oxidative stress development. The aim of our study was to perform molecular docking of hyperoside with the NADPH oxidase enzyme.