Some mechanisms of oncogenic action of human papillomavirus

Abstract

Introduction. Human papillomavirus (HPV) is a large group of common viruses (over 200 types) that can pose a serious health risk. Some HPV types are oncogenic, and at least 25 of these are considered high-risk viruses, as they possess carcinogenic activity and can cause cancer, including cervical, laryngeal, and anal cancers, as well as intraepithelial neoplasia of the vagina and vulva. Anogenital condylomas are very common. However, not all HPV types are dangerous: some cause only benign growths, such as warts. According to the World Health Organization, 40,000 HPV-associated cases of vulvar and vaginal cancer, 100,000 cases of anal cancer, and 400,000 cases of oral and pharyngeal cancer are registered annually.