Titrimetric micro-determination of ethacizine in tablets using oxone

Abstract

Ethacizine (Syn. ethacyzine) is a class Ic antiarrhythmic agent. It is used in Ukraine and some other countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome. Ethacizine Hydrochloride (ETC) is chemically an ω-aminoacyl derivative of phenothiazine, a diethylamine analogue of Moracizine (syn. Etmozine).