Development and Validation of the Iodometric Method for the Quantitative De- termination of Mezlocillin in Pure Substance and Medical Preparation

Abstract

Introduction. Mezlocillin (Mezl) is a 4th generation penicillin antibiotic which kills certain bacteria that cause infection, or stops their growth. It treats many kinds of infections including those of the skin, blood, CNS, respiratory tract, sinuses. This drug is discontinued in the US. Mezl has in vitro activity against gram-positiv and gram-negative aerobic and anaerobic bacteria. The bactericidal ac- tivity of mezlocillin results from the inhibition of cell wall synthesis and is mediated through mezlocillin binding to penicillin binding proteins (PBPs). Mezl is stable against hydrolysis by a vari- ety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta- lactamases.