Electrospun nanofibers loaded with Lavandula angustifolia Mill. extract: A novel approach for a potential wound healing therapy

Abstract

ABSTRACT Background: Lavandula angustifolia Mill. is widely used for its potential health benefits. It has antimicrobial, anti-inflammatory, and wound-healing properties due to the presence of both terpenoids and phenolic compounds. Novel formulations for both oral and topical usage could extend the range of applications.

Methods: In this study, electrospun nanofibers incorporating dry extract of lavender (at 9.09%, 16.67%, and 24.98% w/w) were prepared using polyvinylpyrrolidone (PVP) as a polymer matrix, with the aim of creating fast-dissolving systems.

Results: Fibers produced at 10 kV exhibited uniform morphology, with the 9.09% w/w lavender extract ratio showing the optimum morphology (average diameters: 0.70–1.49 µm). The obtained fibers were smooth, uniform, free of beads, and comprised amorphous solid dispersions. All the fiber formulations rapidly disintegrated and accelerated the dissolution of lavender extract.

Conclusions: These findings highlight the potential of lavender extract-loaded nanofibers as fast-acting delivery systems. This work provides a novel approach for formulating medicinal plant-loaded nanofibers, especially for active ingredients with low solubility, and offers a potential therapy for wound healing.