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Title: Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin- 4-ones as possible anticonvulsant agents
Authors: Severina, A. I.
Georgiyants, V. A.
Shtrygol', S. Yu.
Kavraiskyi, D. A.
Северіна, Г. І.
Северина, А. И.
Георгигіянц, В. А.
Георгиянц, В. А.
Штриголь, C. Ю.
Штрыголь, C. Ю.
Каврайский, Д. П.
Keywords: synthesis;pyrimidine;pyrazole;alkylation;acetamides;activity prediction
Issue Date: 2015
Publisher: Scholars Research Library
Bibliographic description (Ukraine): Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin- 4-ones as possible anticonvulsant agents / A. I. Severina, V. А. Georgiyants, S. Yu. Shtrygol, D. P. Kavraiskyi // Der Pharma Chemica. - 2015. - Vol. 7, №11. - P. 43-48.
Abstract: The synthesis of 1-(4-bromophenyl)- and 1-(2-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one as possible anticonvulsant agents was planned. It was carried out by the interaction of the corresponding phenylhydrazine hydrochloride with ethyletoxymethylencyanocetate with a further heating of obtained 5-аmino-1- аryl-1H-pyrazole-4-carboxylate in excess of formamide. The direction of reaction of 1-aryl-1,5-dihydro-4Hpyrazolo[ 3,4-d] pyrimidine-4-one with N-arylsubstituted α-chloracetamides, 2-chloro-1-(4-arylpiperazine-1-yl)- ethanone and 2-chloro-N-(4-chlorobenzyl)acetamide in the presence of DMFA-NaHCO3 had been investigated. Using the data of NMR and NOESY spectroscopy it was found out that reaction is selectively performed at 5 position of pyrazolo[3,4-d]pyrimidine system. Due to preliminary prognosis of biological activity pharmacological screening of substances synthesized as possible anticonvulsant agents on the penthyltetrazole seizures was planned
ISSN: 0975-413X
Appears in Collections:Наукові публікації кафедри фармакологiї та фармакотерапії
Наукові публікації кафедри фармацевтичної хімії

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