The Study of the Effect of “Candidocyde” Drug on T-, B-Lymphocytes and the γ -Globulin Fraction

Abstract

Year by year the number of patients with candidiasis has increased; it is associated with weakening of the human immunity and increased pathogenicity of a causative agent. At the premises of the National University of Pharmacy at the Biotechnology Department and the Department of Microbiology, Virology and Immunology a potential vaccine - the immunobiological drug "Candidocyde" solution for prevention and treatment of candidal infection has been developed. The aim of this work is to study the values of T-, V-lymphocytes and γ-globulin in rabbits when introducing the solution of the immunobiological drug "Candidocyde". Blood analysis was performed in several groups of animals: 1) intact animals, 2) healthy animals received the solution of the immunobiological drug "Candidocyde", 3) infected animals, 4) infected animals received the solution of the immunobiological drug "Candidocyde". The state of cellular and humoral immunity was assessed by the number of T-, B-lymphocytes and γ-globulin. The blood values in healthy rabbits and rabbits with candidiasis after introduction of the solution of the immunobiological drug "Candidocyde" are characterized by elevation of T-, B-lymphocytes and γ-globulin. The analysis of the data obtained indicates activation of the humoral and partially cellular immunity.