Application of test-kits with heavy metals salts for analysis of salts of benzoic and salicylic acids in extemporal medicines

Abstract

Test systems are simple, effective, affordable and express analysis tools used in medical practice, to diagnose the state of the human organism, and for the quality control of medicines. The aim of the work wasto check the possibility of using test-kits based on filter paper for high-quality rapid analysis of salts of benzoic and salicylic acids while conducting the pharmaceutical analysis of extemporal medicinal preparations (EMP). Test-kits were prepared by the way of physical immobilization of reagents solutions (iron (III) chloride and copper (II) sulfate) on the matrix surface with further drying. The objects of the experiment were 1%, 2% and 5% aqueous solutions of sodium salts of benzoic and salicylic acids. The results of the investigation show that using test-kits based on filter paper with heavy metal salts makes it possible to identify sodium benzoate and sodium salicylate in extemporal medicines: sodium benzoate with the help of test-kits with FeCl3starting from 7 mg/ml (1% aqueous solution) and with the help of test-kits with CuSO4starting from 14 mg/ml (2% solution); sodium salicylate with the help of testkits with FeCl3 and CuSO4starting from 14mg/ml (2% solution).For simultaneous identification of sodium benzoate and sodium salicylate in a polycomponent EMP test-system withCuSO4 can be used.