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http://dspace.nuph.edu.ua/handle/123456789/12109| Title: | In vivo anticonvulsant activity of extracts and protopine from the fumaria schleicheri herb |
| Authors: | Prokopenko, Yu. Tsyvunin, V. Shtrygol, S. Georgiyants, V. Прокопенко, Ю. Цивунін, В. В. Цивунин, В. В. Штриголь, С. Ю. Штрыголь, С. Ю. Георгигіянц, В. А. Георгиянц, В. А. |
| Keywords: | flavonoid fraction;protopine;Fumaria schleicheri;anticonvulsant activity;alkaloid fraction;protein-polysaccharide fraction |
| Issue Date: | 2016 |
| Publisher: | SciPharm |
| Bibliographic description (Ukraine): | In vivo anticonvulsant activity of extracts and protopine from the fumaria schleicheri herb // Yu. Prokopenko, V. Tsyvunin, S. Shtrygol, V. Georgiyants // Scientia Pharmaceutica. – 2016. – № 3, Vol. 84. – P. 547-554. |
| Abstract: | The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleicheri herb and studied along with Fumaria schleicheri dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of Fumaria schleicheri dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity. |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/12109 |
| Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| scipharm-84-00547.pdf | 202,39 kB | Adobe PDF | View/Open |
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