Efficacy of 6-hydroxy-N-(4-methoxyphenyl)-4-oxo- 1,2-dihydro-4Н-pyrrolo[3,2,1-ij]quinoline- 5-carboxamide in modelling renal insufficiency

Abstract

Kidney failure is a severe consequence of chronic kidney diseases, which is accompanied by disorder of kidneys' homeostatic function with development of azotemia, violations of water-electrolyte metabolism and acid-base status with diseases accession, such as anemia, hypertension, and so on. As a result of circulatory disorders in the kidneys, that leads to a delay products in blood which are normally excreted in the urine, the pathological process raises that reflected in the inability of all or most of the nephrons of the kidney to maintain homeostasis - acute renal failure. Taking into consideration the steady trend to the quantity rise of kidney diseases and despite improving the modern methods of prevention and treatment, search for new effective nephroprotective medicines is actual issue. Accordingly, the aim of this work was a research of specific pharmacological activity of substance 6-hydroxy-N-(4-metoxyphenyl)-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide on a model of renal failure. For toxic nephrosis-nephritis modeling, the ethylene glycol was applied by intragastrically administration to rats once in a dosage of 2.5 g / kg, since it is known that it causes classic kidney damage with renal failure and oliguria syndrome. Study of the substance effectiveness was evaluated according to its diuretic action and results of the experimental animals urine analysis. It was established that the stated substance has practically normalized the indices, such as value of рН, protein and urine solidity. The obtained results demonstrate that the substance renews the kidneys' function while serious nephrosis-nephritis, caused by ethylene glycol and has a diuretic action.