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http://dspace.nuph.edu.ua/handle/123456789/14352
Title: | The psycho- and neurotropic profiling of novel 3-(N-R,R′-aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo |
Authors: | Podolsky, I. M. Shtrygol', S. Yu. Подольский, И. Н. Подольський, І. М. Штриголь, С. Ю. Штрыголь, С. Ю. Zubkov, V. O. Зубков, В. О. |
Keywords: | 1H-quinolin-4-ones;open field test;elevated plus maze;acute hypoxia;tail suspension test;passive avoidance test |
Issue Date: | 2018 |
Bibliographic description (Ukraine): | Podolsky, I. M. The psycho- and neurotropic profiling of novel 3-(N-R,R′-aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo / I. M. Podolsky, S. Yu. Shtrygol’, V. O. Zubkov // Saudi Pharmaceutical Journal. – 2017. – Vol. 26. – P. 107–114. |
Abstract: | The article presents the study of psycho- and neurotropic properties of novel 3-(N-R,R0 -aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo. The research was carried out using the open field test, elevated plus maze, rotarod test, tail suspension test, passive avoidance test after scopolamine-induced amnesia and acute normobaric hypoxia with hypercapnia. As a result, two promising substances have been found. According to our results 3-[[(4-methoxyphenyl)amino]methyl]-2-methyl-1H-quinolin-4-one in the dose of 10 mg/kg shows a specific sedative effect and a considerable anti-amnesic activity. The most interesting N-[(2-methyl-4-oxo-1H-quinolin-3-yl)methyl]-N-phenylbenzamide (100 mg/kg) combines a potent anti-anxiety action, the anti-amnesic activity and a considerable antihypoxic effect. They are of interest for further profound studies as promising psychoactive compounds |
URI: | http://dspace.nuph.edu.ua/handle/123456789/14352 |
Appears in Collections: | Наукові публікації кафедри медичної хiмiї Наукові публікації кафедри фармакологiї та фармакотерапії |
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File | Description | Size | Format | |
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The_psycho-_and_neurotropic_profiling_of_novel_3-N.pdf | 949,77 kB | Adobe PDF | View/Open |
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