Effect of the antioxidant – herbal derivate on biomarkers of oxidative stress and an­tioxidant systems on the model of gastric ulcer

Abstract

A definite value in the pathogenesis of peptic ulcer belongs to the activation of lipid peroxidation (LPO) processes. The activity of LPO processes is controlled by antioxidant defense factors, which should have cytoprotective properties. However, with their functional insufficiency, oxidative stress develops, in which LPO products "attack" cellular structures, are accompanied by damage to the lipids of cell membranes, increased permeability and destruction of cells, and contributes to the formation of a ulcerative defect. Phenolic compounds – natural synergists of ascorbic acid, are widely represented in the plant world. Polyphenols of vegetable origin have a number of biological effects, in particular antioxidant and anti-inflammatory effects. Polyphenols of grape seeds are recognized as one of the most powerful among all known natural antioxidants. By activity, they are almost 50 times higher than vitamin E and 20 times – vitamin C. At the same time, these secondary metabolism substances have low bioavailability. The purpose of our study was to study the effect of the liposomal emulsion of grape seed polyphenols (LEGSP) on the state of the system of LPO and antioxidant enzymes of erythrocytes on the model of chronic hydrocortisone gastric ulcer.