The choice of intense sweetener in the composition of medicated chewing gum under development

Abstract

The creation of modern drugs in a rational dosage form with optimal taste characteristics is one of the ways to increase their competitiveness. Taste is one of the characteristic features of a chewing gum, as this product remains in the oral cavity for a longer time than other oral medicines. To ensure a good taste profile of medicated chewing gum (MCG), intense sweeteners are used in pharmacy that not only improve and disguise an unpleasant taste, but also compensate for the lack of sweetness in a sugar-free chewing gum. The object of our research was the MCG we developed with lysozyme hydrochloride and ascorbic acid based on the composition HiG-01 (Cafosa, Spain), recommended for use in dentistry. The purpose of this work was to select the optimal intense sweetener in its composition, as which were investigated: Stevia RN (Germany); Acesulfam K (Germany); Ajinomoto Aspartame Fine Granular 150 (France); Sodium Cyclamate anhydrous powder E-952 (Germany); Sodium Saccharin HQ 15% hydrated E-954 (Germany); Solo Sucralose- Non Micronised NF (India).