Application of an Artificial Neural Network for Design of Sustained-Release Matrix Tablets Containing Vaccinium Myrtillus Leaf Powder Extract

Abstract

Bilberry (Vaccinium myrtillus L.) leaves have long been used as an antidiabetic remedy in folk medicine. In the early scientific research, the bilberry leaf preparations were found to be effective in diabetic conditions as they considerably prolonged the survival time of fully depancreatized dogs and completely normalized the blood glucose level in partially depancreatized dogs.The current in vitro studies revealed that aqueous and hydroethanolic extracts of V. myrtillus leaves possess antioxidant and α-glucosidase-inhibiting activities.It was also reported that bilberry leaf extracts have some agonistic activity on human peroxisome proliferator-activated receptor gamma. Hypolipidemic and hypoglycemic therapeutic potential of bilberry leaf extracts was confirmedby in vivo studies. Recently, the method for preparation of the hypoglycemic composition from V. myrtillus leaves in the form of water-soluble powder extract has been developed. It was identified that the most abundant phytochemical constituent of V. myrtillus leaf extract obtained using this method is chlorogenic acid.Unlike many other plant phenolic compounds (e.g., resveratrol, quercetin, and genistein), chlorogenic acid has good aqueous solubility and is highly absorbed and rapidly eliminated from the human organism.