Formulation of sustained release matrix tablets as an approach to improve antidiabetic efficacy of Vaccinium myrtillus leaf extract

Abstract

Bilberry (Vaccinium myrtillus) leaves belong to promising sources of natural antidiabetic drugs. Bilberry leaf extracts (BLEs) were found to inhibit small intestine enzymes participating in carbohydrate digestion that prevents glucose absorption and decreases glycemic level. Hence, the development of a sustained release (SR) formulation was suggested as an approach to increase the efficacy of BLE. This should contribute to the prolongation of half-life and increasing small intestine concentrations of bilberry leaf polyphenols.