Please use this identifier to cite or link to this item:
http://dspace.nuph.edu.ua/handle/123456789/18946| Title: | A study of the influence of solvents on crystallographic characteristics of local anesthetics |
| Authors: | Kovalevska, I. V. Borko, Ye. A. Poluian, S. M. Ковалевська, І. В. Ковалевская, И. В. Борко, Е. А. Полуян, С. М. |
| Keywords: | lidocaine;benzocaine;trimecaine;solubility;shape factor;sphericity |
| Issue Date: | 2019 |
| Bibliographic description (Ukraine): | Kovalevska, I. V. A study of the influence of solvents on crystallographic characteristics of local anesthetics / I. V. Kovalevska, Ye. A. Borko, S. M. Poluian // Annals of Mechnikov Institute. - 2019. - № 1. - P. 17-22. |
| Abstract: | Esters of para-aminobenzoic acid (PABA) – benzocaine and substituted amides – lidocaine and trimecaine are used in suppositories as substances with anesthetics effect. When benzocaine is used to reduce pain the effect develops for 1 minute after applying of rectal dosage forms and lasts for 20-30 minutes. The maximum effect of lidocaine is manifested within 15-30 minutes after using the medications. Trimecaine is absorbed rapidly and has a period of action of 60 minutes, but in the presence of inflammation, it is possible to decrease the anesthetic activity. The above local anesthetics have a low toxicity, which is an essential aspect in the formation of medications. |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/18946 |
| Appears in Collections: | Наукові публікації кафедри ЗТЛ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ковалевская_Борко.pdf | A STUDY OF THE INFLUENCE OF SOLVENTS ON CRYSTALLOGRAPHIC CHARACTERISTICS OF LOCAL ANESTHETICS | 1,09 MB | Adobe PDF | View/Open |
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